Southern matriarch Madea has a lot on her plate. Her nieces, Vanessa and Lisa, have relationship troubles - Vanessa moves into Madea's house with her 2 young children and Lisa is engaged to a controlling man that her mother set her up with. In addition, Madea has just been court-ordered to become the guardian of Nikki, a rebellious runaway teenager. Madea must keep the peace and her family together while simultaneously planning her clan's reunion.

Genres